National Vaccine Information Center

Standard-Dose Inactivated Flu Vaccine

Published: August 23, 2024

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The most common flu vaccine is the inactivated (killed) influenza vaccine, which is prepared from the fluids of chick embryos inoculated with a specific type(s) of influenza virus.   The strains of flu virus in the vaccine are inactivated with formaldehyde and preserved with thimerosal, which is a mercury derivative.  (There is a limited supply of thimerosal-free or influenza vaccine with trace amounts of thimerosal and it is supplied in single dose vials, which do not require a preservative). This type of inactivated influenza vaccine is administered by injection into the muscle and contains three (trivalent) influenza virus strains – two type A and one type B strains.  One flu vaccine, Afluria, is given by jet injector, a medical device which uses high pressure to administer the vaccine. 

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