DAPTACEL is a 3 in 1 shot (diphtheria, tetanus, acellular pertussis vaccines) given to infants and children 6 weeks though 6 years of age. (see Sanofi Pasteur product insert for recommended schedule and other indications).
- Vaccine ingredients: Aluminum phosphate, formaldehyde, ammonium sulfate, modified Mueller-Miller casamino acid medium without beef heart infusion, glutaraldehyde, 2-phenoxyethanol, Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin, Mueller’s growth medium.
- Estimated Efficacy: In a U.S study of children who received four doses of DAPTACEL vaccine at two, four, six and 15-17 months, after administration of the third dose of vaccine (at six months of age), 100 percent of vaccine recipients were found to have blood antibody levels indicative of protection. Following administration of the fourth dose of DAPTACEL, 96.5 percent of children sampled were found to have levels of blood antibodies considered to be protective against diphtheria disease.
- Use with Other Vaccines: In clinical trials, DAPTACEL was given with HIB, inactivated polio (IPV), hepatitis B, pneumococcal, and MMR or varicella vaccines. There is no information in the package insert about the safety or effectiveness of giving DAPTACEL simultaneously with inactivated or live influenza, rotavirus, or hepatitis A vaccines. DAPTACEL has been noted to reduce meningococcal antibody responses to Menactra when administered one month after Menactra. In cases where DAPTACEL and Menactra are to be administered, the vaccines are recommended to be given at the same time or else one month apart, with Menactra administered first.
Animal reproduction studies have not been conducted with DAPTACEL. It is not known whether DAPTACEL can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. DAPTACEL has not been evaluated for carcinogenic or mutagenic potential, or for impairment of fertility.
